EPIGENETIC PROFILING REVEALS A UNIQUE HISTONE CODE IN CHORDOMA

Neurosurgery(2016)

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摘要
INTRODUCTION:Pathognomonic genetic “driver” lesions to explain the brachyury transcriptional program have not been described in chordoma. Herein we characterize the epigenetic histone, methyl-genomic, and somatic chromatin-modifying genotypic (CMG) landscape of chordoma.METHODS:Six chordomas with ma
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