BARD1 splice variants display mislocalization in breast cancer cells and can alter the apoptotic response to cisplatin.

Kamila A. Marzec,Estefania Martino-Echarri,Irmgard Irminger-Finger,Beric R. Henderson

Cancer Letters（2016）

引用 8|浏览5

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摘要

•BARD1 splice variants display altered subcellular localization.•BARD1-beta and -omega lack a nuclear export sequence and accrue in the nucleus.•Nuclear-located beta and omega isoforms are less apoptotic in MCF-7 cells.•BARD1-epsilon lacks a nuclear localization signal and accumulates in the cytoplasm.•BARD1 variant mislocalization can alter breast cancer cell apoptotic responses.

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关键词

BARD1,Breast cancer,Splice variants,Nuclear localization,Cisplatin,Apoptosis

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