The efficacy of acarbose in the treatment of patients with non-insulin-dependent diabetes mellitus

Objective: To evaluate the long-term efficacy of acarbose, an α-glucosidase inhibitor, in improving glycemic control in patients with non-insulin-dependent diabets mellitus. Design: A 1-year, multicenter, randomized, double-blind, placebo-controlled study. Setting: Seven university-affiliated, community-based, tertiary care diabetes clinics. Patients: 354 patients with non-insulin-dependent diabetes mellitus were recruited; 77 were being treated with diet alone, 83 with diet and metformin, 103 with diet and sulfonylurea, and 91 with diet and insulin