Differential brain response to successful and failed response inhibition: Cocaine-dependent vs. healthy subjects

to GDC (n=58). Characteristics of women with a history of sexual abuse were examined in these post-hoc analyses. Methods: Participants ≥18 years with SUDs were included if they used substances in past 60 days. Sexual abuse (SA) history was assessed using the Life ExperiencesQuestionnaire; functioning with theGlobalAssessmentof Functioning (GAF) scale; and theCIDI was used to determine psychiatric diagnoses. Results: Of the 100 women in the trial, 39% reported a history of SA. Compared to women without a history of SA, those with a SA history had lower GAF scores (t=2.7, df = 98, pu003c .01) and higher rates ofmajor depressive disorder (85% vs. 64%; 2(1) =5.05, pu003c .05), PTSD (39% vs. 13%; 2(1) =8.63, pu003c .01), and panic disorder (26% vs. 8%; 2(1) =5.68, pu003c .05).We dividedwomen into 3 groups: (1) no history of SA, (2) SA either before OR after age 16, and (3) SA before AND after age 16. Women with abuse before and after had the lowest GAF scores (M=56, SD=4.7), followed by those with one type of abuse (M=59, SD=5.7); women with no history had the highest GAF scores (M=61, SD=5.3). Women assigned to the GDC group who had a history of SA rated the helpfulness of having men and women in the group as significantly lower than those without a history of SA (t=−2.4, df = 40, pu003c .05);women in theWRG rated the helpfulness of the all-women group composition as high regardless of SA history. Conclusions: Women with SA history had lower functioning and greater psychiatric comorbidity. Single-gender SUD group composition was endorsed as helpful by those with and without SA history but may be especially importantfor those who have experienced sexual abuse. Financial Support: NIDA R01 DA015434 and K24 DA019855.