Molecular and Epigenetic Features of Melanomas and Tumor Immune Microenvironment Linked to Durable Remission to Ipilimumab-Based Immunotherapy in Metastatic Patients

Teofila Seremet,Alexander Koch,Yanina Jansen,Max Schreuer,Sofie Wilgenhof,Véronique Del Marmol,Danielle Liènard,Kris Thielemans,Kelly Schats,Mark Kockx,Wim Van Criekinge,Pierre G. Coulie,Tim De Meyer,Nicolas van Baren,Bart Neyns

Journal of translational medicine（2016）

引用 28|浏览36

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摘要

Ipilimumab (Ipi) improves the survival of advanced melanoma patients with an incremental long-term benefit in 10–15 % of patients. A tumor signature that correlates with this survival benefit could help optimizing individualized treatment strategies.

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关键词

Translational research,Durable remission,Ipilimumab,Immunotherapy,Metastatic melanoma

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