Synthesis of Enantioenriched a,a-Disubstituted Cyclopentenes Catalyzed by N-Heterocyclic Carbenes
Synthesis(2009)
摘要
rhe desymmetrization of 1,3-diketones using N-heterocyclic carbenes results in the formation of highly enantioenriched cyclopentenes in good yield. The reaction proceeds through a catalytic intramolecular aldol reaction and subsequent β-lactone formation. The expulsion of carbon dioxide at mild reaction temperatures affords the cyclopentene products.
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