Lenalidomide Promotes A Pro-Inflammatory Switch of Nurse-Like Cells Derived from Chronic Lymphocytic Leukemia

Rossana Maffei,Stefania Fiorcari,Silvia Martinelli,Jenny Bulgarelli,Valentina Audrito,Patrizia Zucchini,Giulia Debbia,Elisabetta Colaci,Leonardo Potenza,Franco Narni,Silvia Deaglio,Mario Luppi,Roberto Marasca

Blood（2014）

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摘要

Lenalidomide is an immunomodulatory agent clinically active in CLL patients. The specific mechanism of action is still undefined, but includes the modulation of microenvironment. In CLL patients, nurse-like cells (NLCs) differentiate from CD14+ mononuclear cells and nurture/protect CLL cells from apoptosis. NLCs resemble M2 macrophages with potent immunosuppressive functions.

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