DNA maintenance following bleomycin-induced strand breaks does not require poly(ADP-ribosyl)ation activation in Drosophila S2 cells

Layal Ishak,Amandine Moretton,Isabelle Garreau-Balandier,Mathilde Lefebvre,Serge Alziari,Philippe Lachaume,Frédéric Morel,Géraldine Farge,Patrick Vernet,Pascal Dubessay

DNA Repair（2016）

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摘要

•Bleomycin-induced DNA breaks generate low PARylation response in S2 cells.•Oxidative stress and DNA breaks involve differential PARylation response in S2 cells.•PARG is essential for regulation of PARylation processes towards genotoxic stress.•PARP is an actor of DNA maintenance in the lack of exogenous stresses.

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关键词

PARP,PARG,PAR,SSB,DSB

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