Characterizing the mode of action of extracellular Connexin43 channel blocking mimetic peptides in an in vitro ischemia injury model

Yeri Kim,Jarred M. Griffin,Paul W. R. Harris,Sin Hang Crystal Chan,Louise F.B. Nicholson,Margaret A. Brimble,Simon J. O'Carroll,Colin R. Green

Biochimica et Biophysica Acta (BBA) - General Subjects（2017）

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摘要

•A molecular mode of action of Connexin43 mimetic peptide (Peptide5) is proposed.•Peptide5 blocks Connexin43 hemichannel-mediated ATP release.•Peptide5 acts on the extracellular loop two of Connexin43.•Peptide5 sequence specificity is required for hemichannel block.•The SRPTEKT motif is central to Peptide5 mechanism.

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关键词

CNS,hCMVEC,ATP

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