Infusion of fluoxetine, a serotonin reuptake inhibitor, in the shell region of the nucleus accumbens increases blood glucose concentrations in rats

•Fluoxetine infused in the nucleus accumbens shell (sNAc), increases blood glucose.•Fluoxetine’s effects were partly explained by increased glucose production.•Effect of fluoxetine in sNAc is independent of glucoregulatory hormones changes.•We show first support for a role of the cortico-limbic system in glucose metabolism.