Activity limitations in myasthenia gravis and relation to clinical variables.

Introduction: It is unknown how fluctuations in muscle weakness affect activity limitations in myasthenia gravis patients and how the severity of these limitations compares with published data on other neuromuscular disorders (NMD). Methods: In this study we analyzed ACTIVLIM (acronym of "ACTIVity LIMitations") and quantitative myasthenia gravis (QMG) scores. We assessed the impact of QMG and other clinical variables on ACTIVLIM, using B coefficients. Results: The mean ACTIVLIM score in 118MG patients was 3.3. There was a correlation between QMG and ACTIVLIM (B coefficient=-0.206, P< 0.001) and between changes in both scores (B coefficient=-0.175, P=0.002). Men and patients without another autoimmune disease had a better ACTIVLIM score (B coefficient=0.785, P=0.015 and B coefficient= 0.998, P=0.008, respectively). Conclusions: The ACTIVLIM score in MG is higher than in other NMD. Fluctuations in QMG correlated significantly with changes in ACTIVLIM.