Group comparison of cortical fiber connectivity map: An application between post-stroke patients and healthy subjects.

•This study showed the feasibility of applying group comparison vertex-wise analysis for cortical structural connectivity.•A fiber connectivity density (FiCD) method based on connectome method was applied to measure whole-brain FiCD map.•Stroke and healthy participants were enrolled for the FiCD measurement and their FiCD maps were statistically compared.•There was a spatial consistency between the cortical clusters with low FiCD values and the subcortical lesions of patients.•The FiCD method possessed good reproducibility, and could accurately reflect the affected cortical regions in patients.