Cost-effectiveness of a cascade screening program for the early detection of familial hypercholesterolemia

•Familial hypercholesterolemia (FH) confers a high risk of coronary artery disease.•However, most FH patients are undiagnosed.•The efficiency of genetic cascade screening programs at national level is unknown.•The program implantation avoids a relevant number of coronary events and deaths.•The cost per quality-adjusted life year gained is within the social and ethically acceptable threshold.