Abstract P022: Association of Longitudinal Change in Kidney Function with Left Ventricular Structure and Function as Measured by Cardiac MRI: The Multi-Ethnic Study of Atherosclerosis (MESA)

Background: This study examines the association of change in estimated glomerular filtration rate (eGFR) with change in left ventricular (LV) structure and function over 10 years of follow-up.Method: MESA participants with cardiac magnetic resonance imaging (CMR) measures and eGFR measured at both baseline (2000-2002, year-0) and the 10 year follow-up (2010-2012, year-10) exam were studied. Participants with cardiovascular disease (CVD) were excluded. LV mass and volume indexed to body surface area, LV ejection fraction (LVEF), and LV mass volume ratio (MVR) were determined by CMR. We stratified participants by the presence of eGFR u003c 60 ml/min/m2 at baseline and at year 10 into 4 groups; eGFR ≥60 at both year-0 and year-10 (reference), ≥60 at year-0 and u003c60 at year-10, u003c60 at year-0 and ≥60 at year-10, and u003c60 at both year-0 and 10. Multiple linear regression models were used to evaluate the association between eGFR groups and change in LV parameters (year-10 - year-0) after adjusting for the demographics, baseline CVD risk factors, change in risk factors, and baseline LV parameters.Results: 2,722 participants (age 59 ± 9 years, 53% women, 42% White, 13% Chinese, 25% African American, 20% Hispanic) were included. Compared to the reference group, the group with eGFR ≥60 at year-0 and u003c60 at year-10 and the group with eGFR u003c60 at both year-0 and 10 group showed increasing MVR during 10 year follow-up. No difference in longitudinal change in LV mass or LVEF by eGFR groups were noted (Table).Conclusion: In this multi-ethnic cohort of adults without clinical CVD, reduced eGFR at baseline or during follow-up was associated with the development of concentric remodeling represented by increased MVR. ![][1] [1]: /embed/graphic-1.gif