Ryanodine receptor modification and regulation by intracellular Ca 2+ and Mg 2+ in healthy and failing human hearts.

K Walweel,P Molenaar,M S Imtiaz, A Denniss,C Dos Remedios,D F van Helden,A F Dulhunty,D R Laver,N A Beard

Journal of molecular and cellular cardiology（2017）

引用 31|浏览19

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摘要

Despite different aetiologies, disrupted RyR2 Ca sensitivity and biochemical modification of the channel are common constituents of failing heart RyR2 and may underlie the pathological disturbances in intracellular Ca signalling.

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关键词

Heart failure,Lipid bilayer,Mg(2+) and Ca(2+) signalling,Phosphorylation,Regulatory proteins,Ryanodine receptor

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