Preventative Effect Of Glucolysis Inhibitor On Acute Graft Versus Host Disease In Mice After Allogenic Bone Marrow Transplantation

Background: T-cell activation plays a critical role in the pathogenesis of acute graft-versus-host disease (aGVHD). Quiescent T cells utilize oxidative phosphorylation to generate ATP, whereas activated T cells utilize glycolysis, so using glycolysis inhibitor may be a metabolically regulator needed to control T cells inducing GVHD. Glucolysis inhibitor 3-Bromopyruvic acid (3-BrPA), a glucolysis inhibitor, can effectively induce multi-drug resistance leukemia cell lines apoptosis and enhance chemotherapy-induced cytotoxity to leukemia cells.