Enantioselective Synthesis of Cephalimysins B and C

David Chalupa,Petra Vojáčková, Jiří Partl,Dražen Pavlović,Marek Nečas,Jakub Švenda

Organic Letters（2017）

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摘要

The first synthesis of cephalimysins B and C is reported. The route features a Ni(II)–diamine-catalyzed enantioselective conjugate addition of a densely substituted 3(2H)-furanone and an efficient dihydroxylation–lactonization sequence as key steps in the assembly of the spirocyclic core. The fully synthetic strategy is amenable to analog preparation.

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enantioselective synthesis

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