Resection Rate And Operability Of Elderly Patients With Non-Small Cell Lung Cancer: Nationwide Study From 1991 To 2014

OBJECTIVES: An increasing number of elderly patients are diagnosed with non-small cell lung cancer (NSCLC). We compared the surgical resection rate, operability and survival in this age group (>= 75 years) to younger patients using centralized databases in Iceland.METHODS: The study population comprised all patients diagnosed with NSCLC in Iceland from 1991 to 2014. A total of 140 elderly patients (>= 75 years) with NSCLC underwent pulmonary resection and were compared with 550 surgically resected patients less than 75 years, with respect to resection rate, short and long-term survival and complications of surgery. Reasons for exclusion from surgery were registered for elderly surgical candidates (stages IA-IIB).RESULTS: Surgical resection rate in the elderly group was 18% compared to 32% in the younger age group (P<0.001). The most frequent reasons for not operating on elderly patients in stages IA-IIB were poor pulmonary function (58%), heart disease (17%) or multiple comorbidities (17%). The rate of major complications following surgery was comparable in the elderly versus the younger age group, 13 vs 11%, respectively (P=0.578). The same was true for 30 day mortality (2 vs 1%, P=0.397). Five-year overall survival was 40% vs 44% (P=0.019) and cancer-specific survival 51% vs 50% (P=0.802).CONCLUSIONS: Elderly patients with resectable NSCLC according to stage are frequently excluded from surgery due to comorbid conditions. Although the operated patients may represent a selected group, their favourable 30-day and long-term survival indicate that more elderly patients with NSCLC could be operated on.