Cerebral Vasculopathy Outcome In A Sickle Cell Anemia (Sca) Newborn Cohort Screened Early With Transcranial Doppler

Background: Stroke is the most severe complication in children with SCA and has been reported to concern 11% of patients by the age of 18 years. Transcranial Doppler detects patients at risk for stroke and transfusion program significantly reduces the risk of stroke in patients with abnormal TCD (Adams, NEJM 1998, 2005). However, the estimate of overt and silent strokes occurrence in a newborn SCA cohort explored early with TCD has not yet been reported.