STAT5-Regulated Mirna193b Controls Hematopoietic Stem and Progenitor Cell Expansion by Fine Tuning Cytokine Signaling

Hematopoietic stem cells (HSCs) regenerate the blood system life-long. Their number must be strictly controlled to avoid either exhaustion or excessive expansion leading to leukemia. Not only proteins but also regulatory RNAs are necessary to maintain HSCs. Hematopoiesis requires the right composition of microRNAs (miRNA), small, non-coding RNAs with the ability to simultaneously target multiple mRNAs for the orchestration of complex gene expression networks.