Efficacy Comparison of Oral Versus Intravenous Busulfan in a BuCy Conditioning Regimen for Allogeneic BMT.

Intravenous administration of busulfan (I-Bu) or targeted busulfan dosing has replaced oral administration of busulfan (O-Bu) in a conditioning therapy for BMT mainly due to erratic gastrointestinal absorption of oral busulfan. Several retrospective study results have demonstrated that use of I-Bu resulted in lower transplant-related morbidity and mortality compared to O-Bu, but the efficacy of I-Bu and O-Bu has not been compared. In this retrospective study, we compared the efficacy of I-Bu vs. O-Bu in a BuCy conditioning regimen for allogeneic BMT in a single institute. To avoid the bias of retrospective comparison, we restricted the patient eligibility to the followings: