Identifying Actionable Targets In Advanced Cancer Patients: Preliminary Results From The Profiler Program.

2621 Background: The ProfiLER study was designed to characterize tumor genomic alterations (GAs) in a panel of selected genes in patients (pts) with advanced malignancies. Whether the presence of GAs may guide treatment (trt) decision regardless of histological subtype remains unclear. Methods: Pts with advanced solid and hematologic cancers were offered a genetic profiling of their tumor. DNA extracted from archival or freshly collected tumor samples was analyzed by sequencing of 59 cancer-related genes (NGS, Ion Torrent PGM system) and whole genome CGH array (Agilent platform). A multidisciplinary panel of clinicians and scientists reviewed results to determine the relevance of GAs and recommended molecular targeted therapies (MTT) when relevant. Results: From March to October 2013, 431 pts from a single center were consented and 283 (66%) had their tumor analyzed, either by NGS+CGH (186 pts, 66%), NGS alone (86, 30%) or CGH alone (11, 4%). 137 (48%) had at least one actionable target (AT) with a recomm...