Assessment Of Overall Survival From Time Of Metastastasis In Mucosal, Uveal, And Cutaneous Melanoma.

JOURNAL OF CLINICAL ONCOLOGY(2014)

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摘要
9074 Background: Rarer subtypes of melanoma such as mucosal melanoma (MM) and uveal melanoma (UM) are thought to be associated with worse prognoses than cutaneous melanoma (CM). Comparison of OS in pts with MM, UM and CM after diagnosis of stage IV disease, however, has not been rigorously evaluated. Methods: We conducted a single-center, retrospective analysis of 2920 pts diagnosed with stage IV melanoma between 2000 and 2013 identified from a prospectively maintained database. Melanoma subtype, date of diagnosis of stage IV disease and date of death were extracted, as were established prognostic variables including age at diagnosis of metastasis, gender and M-stage. Results: MM (n=237): median (med) age 66 years (yrs; range 26-91); 65% female; M1a/b/c - 8%/21%/71%. UM (n=286): med age 63 yrs (range 16-86); 46% female; M1a/b/c - 5%/8%/87%. CM (n=2397): med age 62 yrs (range 3-97); 34% female; M1a/b/c - 14%/31%/55%. Differences in age, gender and M-stage were significantly different between groups (p=0.00...
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