MP19-02 SALIVARY NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (NGAL) AND CORTISOL MEASUREMENT IN ACUTE RENAL COLIC

You have accessJournal of UrologyStone Disease: Basic Research & Pathophysiology II1 Apr 2017MP19-02 SALIVARY NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (NGAL) AND CORTISOL MEASUREMENT IN ACUTE RENAL COLIC Ashraf Tamimi, Eyal Kord, Yishai Rapaport, Ramziya Abu hamad, Shai Efrati, Amnon Zisman, and Yoram Siegel Ashraf TamimiAshraf Tamimi More articles by this author , Eyal KordEyal Kord More articles by this author , Yishai RapaportYishai Rapaport More articles by this author , Ramziya Abu hamadRamziya Abu hamad More articles by this author , Shai EfratiShai Efrati More articles by this author , Amnon ZismanAmnon Zisman More articles by this author , and Yoram SiegelYoram Siegel More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.3244AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Introduction: In acute ureteral stone obstruction the decision to treat is sometimes missing a forecaster for a better outcome. Neutrophil Gelatinase-Associated Lipocalin (NGAL) levels are predictive biomarker of Acute Kidney Injury (AKI) with correlation to complication and survival in major surgery. NGAL is particularly expressed during the first 24 hours in the proximal tubules. Cortisol levels in saliva found to be a reliable parameter for stress. Salivary levels of NGAL during renal colic were not evaluated so far. OBJECTIVE To measure salivary NGAL and Cortisol levels in patients presented to the Emergency Room (ER) with acute renal colic. METHODS Prospective controlled study of all patients who presented to ER with acute renal colic and diagnosed with single ureteric stone obstruction by non-contrast computed tomography (NCCT). Saliva, urine and blood samples were collected in patients and control group during the first morning of admission. Salivent system was used to collect the salivary samples for Human Lipocalin-2/NGAL Quantikine ELISA Kit test and for Cortisol. A questionnaire was used to evaluate patient's repose, and clinical data were collected. RESULTS 44 patients in the study group, 13 in the control group, mean age 48±13 years, BMI 28±6, mean stone size 6±4 mm, mean VAS scored of 7±2, mean creatinine levels of 1.3±0.3 mgr/dl, mean WBC 10,900±3,100 count per field, CRP 29±55 .23 (53%) of patient underwent urgent intervention. Serum (199±154 vs 81±24, p < 0.001) and, predominantly Salivary (474±185 vs 328±134; p < 0.05) NGAL levels were significantly elevated in patients with acute renal colic in comparison to controls. Cortisol level on the contrary did not demonstrate any increase during acute phase of renal colic, suggestive a delay response or suppression mechanism. CONCLUSIONS Salivary and blood NGAL sampling is feasible during acute phase of renal colic. High levels of salivary NGAL are observed in a single sampling during acute ureteral stone obstruction and may advance clinical decision making. Cortisol levels fail to increased suggestive of some suppression mechanism. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e229 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Ashraf Tamimi More articles by this author Eyal Kord More articles by this author Yishai Rapaport More articles by this author Ramziya Abu hamad More articles by this author Shai Efrati More articles by this author Amnon Zisman More articles by this author Yoram Siegel More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...