Effect of enzyme inhibition on perampanel pharmacokinetics: Why study design matters
Epilepsy Research(2017)
摘要
•PER has a long t½, averaging 105h.•Study design is critical for interpreting PK data of compounds with a long t½.•With a short-term dosing design, ketoconazole had a negligible effect on PER PK.•A larger effect is predicted if co-administration continues for a longer period.
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关键词
AED,ANOVA,AUC,AUC0-inf,BCRP,BID,CI,CLint,Cmax,Cmin,DDI,ECG,FDA,PBPK,PER,PGTC,PK,QD,t1/2,tmax
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