Su1305 Being More Confidently Conservative: Mutational Profiling of Non-Diagnostic Cytology Samples in Patients with Solid Pancreato-Biliary Lesion (SPL) Impacts Clinical Decision Making

Cytology samples are non-diagnostic (non-assessable, inadequate, atypical, suspicious) in a significant number of patients with SPL, resulting in further expensive testing, delayed or missed diagnosis, and even inappropriate surgical intervention. Integrated mutational profiling (IMP) of cell free supernatant fluid DNA and/or micro-dissected cytology slide specimens has been shown to improve diagnostic accuracy but impact on clinical management is uncertain.