Clustering By Salience Network Activation To Emotional Faces Identifies A Transdiagnostic Subtype That Is Associated With Specific Interoceptive Related Symptoms

Dysfunctions within the salience network, particularly regions of the anterior insula and dorsal anterior cingulate cortex (dACC), are common across anxiety and depression at rest and in response to emotional stimuli. These regions are also implicated in interoception, or the monitoring of one’s internal state. We tested whether a data-driven approach would identify relationships between profiles of salience network activation and specific symptoms related to salience network functions, including interoception, that would cut across current diagnostic boundaries.