Multiplex profiling identifies distinct local and systemic alterations during intraperitoneal chemotherapy for ovarian cancer: An NRG Oncology/Gynecologic Oncology Group Study

Shannon Grabosch,George C. Tseng,Robert P. Edwards,Heather A. Lankes,Kathleen N. Moore,Kunle Odunsi,Anda M. Vlad,Tianzhou Ma,Mary Strange,Joan Brozick,Amit A. Lugade,Angela Omilian,Wiam Bshara,Ashley Stuckey,Joan L. Walker,Michael J. Birrer

Gynecologic Oncology（2017）

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摘要

•Sampling the tumor microenvironment is feasible via IP chemotherapy catheters.•Intraperitoneal biomarkers undergo unique changes not identified in systemic samples.•Multiplex biomarker analysis during chemotherapy provides insight to tumor involution.

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关键词

Ovarian cancer,IP chemotherapy,Immunity,miRNA,IP wash,IP fluid

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