Clinical and diagnostic relevance of NOTCH2-and KLF2-mutations in splenic marginal zone lymphoma.

Yolanda Campos-Martín,Nerea Martínez,Azahara Martínez-López,Laura Cereceda,Felipe Casado,Patrocinio Algara,David Oscier, Francisco J Menarguez,Juan F García,Miguel A Piris,Manuela Mollejo

HAEMATOLOGICA（2017）

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摘要

Splenic marginal zone lymphoma (SMZL) is a small B-cell lymphoma distinguished by frequent 7q loss and the biased use of IGHV01-02. Massive sequencing techniques have demonstrated NOTCH2 -and KLF2 -gene mutations to be the most frequent mutations in SMZL, with NOTCH2 -mutations occurring in 10–25

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