MP081RENAL AGEING AND GLYCATION: IMPLICATION OF RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS

active patients was significantly lower than that in SLE stable patients (P<0.05). The AUC of evaluation for SLE disease activity was 0.856 (0.721, 0.992). The specificity and sensitivity were 0.769 and 0.867, respectively. The levels of miR-223 and miR-20a were significantly decreased in SLE patients (P = 0.019; P = 0.023), and the expression of miR-16 was significantly lower in patients with non-primary SLE P=0.045). CONCLUSIONS: Our study showed 4 B-cell-related miRNAs(miR-19b, miR-25, miR93 and miR-15b) were differentially expressed in the plasma of SLE patients with active or stable phase, this may be of important clinical significance.