Acute myeloid leukemia stem cell function is preserved in the absence of autophagy.

Amy Porter,Lucie Leveque-El Mouttie,Therese Vu,Claudia Bruedigam,Joanne Sutton,Sebastien Jacquelin,Geoffrey R. Hill,Kelli P. A. MacDonald,Steven W. Lane

HAEMATOLOGICA（2017）

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摘要

Autophagy is a complex cellular process that regulates the processing and degradation of intracellular proteins and organelles.[1][1] Within the hematopoietic system, autophagy has diverse roles and is required for hematopoietic stem cell (HSC) function,[2][2] differentiation into erythroid[3][3] or

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