Epidemiology of Cerebrovascular Disease among Chinese Canadians with Diabetes

Abstract Background First-generation Chinese Canadians have usually maintained different lifestyles before immigration to North America, and the question of whether Chinese Canadians with type 2 diabetes have a different stroke profile than that of non-Chinese Canadians remains unanswered. Objectives To determine whether 1) Chinese Canadians who have had a stroke within the last 15 years are more likely to have diabetes than non-Chinese Canadians and 2) to explore differences in stroke profiles between the 2 cohorts. Methods Age- and sex-matched Chinese Canadians (n=70) and non-Chinese Canadians (n=107) were compared on the basis of stroke type, age at stroke onset, stroke etiology and common risk factors. Classifications for disease were done according to professional guidelines. Statistical analysis was done with Student t test and odds ratios to confirm differences between groups. Results Chinese Canadians with stroke had a higher frequency of diabetes mellitus than non-Chinese Canadians. Chinese Canadians with diabetes were more likely to have small vessel disease, specifically lacunar stroke. Chinese Canadians at high risk for stroke were more likely to have a poor prognosis than non-Chinese Canadians, with near significance. Conclusion Chinese Canadians with diabetes who had ischemic strokes were especially susceptible to intracranial small vessel disease compared with non-Chinese Canadians. These results signify that risk factor prevalence and stroke types differ considerably between Chinese Canadians and non-Chinese Canadians residing in Toronto, warranting further study.