JAK1 somatic mutation in myeloproliferative neoplasm

Suzanne O. Arulogun, Hock-Choong Lai, Debbie Taylor,Paula Ambrosoli,Graham Magor,Ian M. Irving,Tee-Beng Keng, Yasmin Harvey,Andrew C. Perkins

Pathology（2018）

引用 8|浏览20

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摘要

The Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) pathway plays a key oncogenic role in blood cancers, particularly myeloproliferative neoplasms (MPNs) and acute lymphoblastic leukemia (ALL). In normal cells, cytokine-induced activation of the JAK/STAT pathway stimulates

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