Promoter interactions direct chromatin folding in embryonic stem cells
NATURE STRUCTURAL & MOLECULAR BIOLOGY（2017）
摘要
The spatial organization of the genome profoundly influences how genes are regulated in normal development or dysregulated in disease. A new study of the murine HoxB locus illustrates how promoter interactions direct higher-order chromatin folding.
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关键词
Chromatin structure,Pluripotent stem cells,Systems biology,Life Sciences,general,Biochemistry,Protein Structure,Membrane Biology,Biological Microscopy
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