Screening With Low-Dose Computed Tomography (Ldct) Of Asbestos-Exposed Subjects And Lung Cancer (Lc) Mortality

1554Background: Our prospective non-randomized ATOM002 study showed that LDCT screening of asbestos-exposed subjects can identify LC at an earlier, potentially more curable, stage than chest radiographs (CXR) (Fasola et al, The Oncologist 2007). The ATOM002 cohort was selected from subjects enrolled in a surveillance program with annual CXR for asbestos exposed workers at the Monfalcone Occupational Health Unit, in the Friuli Venezia Giulia (FVG) region, Italy. Here, we report a cohort mortality study of asbestos exposed subjects from that surveillance program, comparing outcomes in the ATOM002 participants (P) and contemporary nonparticipants (NP). Methods: Within a cohort of 2,433 asbestos-exposed subjects, we compared mortality between the ATOM study P (who had additional baseline and 1 year LDCT) and NP (n = 926 and 1,507, respectively). The follow-up period spanned the years 2002-2011. We performed Cox models to assess survival for all causes, all cancers, LC and malignant pleural mesothelioma. Final...