Effectiveness Of Tablet Family History Collection In A Multidisciplinary Pancreatic Tumor Clinic In Identifying Patients With Risk Factors For Hereditary Cancer

JOURNAL OF CLINICAL ONCOLOGY(2017)

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摘要
e13020Background: A substantial percentage of patients with pancreatic adenocarcinoma (PDAC) harbor pathogenic germline variants in known cancer risk genes, some with relevance for treatment options. Robust collection of relevant personal and family cancer history risk factors for all patients with PDAC is needed to optimize identification of those who could benefit from genetic counseling and testing (GC/GT). Methods: 464 adult patients (≥18 years of age) presenting to a multi-disciplinary pancreatic tumor clinic were invited to complete a tablet based family cancer history survey prior to their clinic appointments. Standard family history entry into electronic medical record (EMR) was reviewed for comparison. Eight GC/CT referral criteria were developed based on existing guidelines for known syndromes associated with PDAC, reported findings from studies of GC/GT outcomes in patients with PDAC, and expert opinion. Presence of any of the 8 criteria were documented for both tablet and EMR collection method...
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关键词
cancer susceptibility,Cancer Genomics,Cancer Risk,Pancreatic Cancer,Genetic Testing
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