Neural Probe with Multiple Optical Stimulation in Depth Direction

In this paper, tube-shaped neural probe that has eight recording areas and three optical emitting points using with optogenetics technique for neural circuit analysis has been developed. Outer diameter of tube is 360 m, the recording areas and the optical emitting points arranged in a depth direction. The optical emitting points make it possible to stimulate neurons in various depth areas respectively. We demonstrated the recording and stimulating of neurons in vivo experiment. As the result, the probe got light-induced neural activities at all the optical emitting points.