ROS is the boss

Jonas Hahn, Deborah Kienhöfer, Julia Stoof,Janka Zsófia Csepregi,Christiane Reinwald,Christian Maueröder,Vilma Urbonaviciute,Luis E. Munoz,Malin Hultqvist,Malgorzata J. Podolska,Mona Hc Biermann,Moritz Leppkes,Martin Herrmann,Thomas Harrer,Attila Mócsai,Rikard Holmdahl,Georg Schett,Markus Hoffmann

Free Radical Biology and Medicine（2018）

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摘要

The production of reactive oxygen species (ROS) via the oxidative burst has been connected with promotion of inflammation and tissue damage, but in recent years has been implicated in regulation of inflammation. We investigated the effects of ROS on the murine model of lupus and in patients (SLE).

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关键词

Murine lupus,ROS,NOX2 agonist,Phagocytosis,NETosis

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