Cross-Platform Integrative Analysis Of Nsclc Reveals Association Between Pd-L1 Expression Patterns And Tumor Genetic Profile

Robin Edwards,Patrik Vitazka,Peter Szabo,Han Chang,John Cogswell,Hao Tang, Kaushal Desai, Darren Locke,Qiuyan Wu,Joseph D. Szustakowski,Steven H. Bernstein, Michele Cleary

CANCER RESEARCH（2017）

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摘要

Background: Immunotherapy with PD-1 inhibitors is associated with increased survival in NSCLC. While PD-L1 expression enriches for clinical benefit, additional predictive biomarkers are critically needed to further define patient subsets associated with specific response/resistance profiles and to develop optimal combination strategies. We hypothesized that integration of pathology features derived from HE 6 squamous cell carcinoma) were included. HE 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 593. doi:10.1158/1538-7445.AM2017-593

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