Synthesis and Anti-HSV-1 Activity of 1,4-dihydro-4-oxoquinoline Ribonucleosides

Carla Veronica B. dos S. Canuto,Claudia R. B. Gomes,Isakelly P. Marques,Letícia V. Faro,Fernanda da C. Santos,Izabel C.P.P. Frugulhetti,Thiago Moreno L. Souza,Anna C. Cunha,Gilberto A. Romeiro,Vitor F. Ferreira,Maria Cecília B. V. de Souza

LETTERS IN DRUG DESIGN & DISCOVERY（2007）

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摘要

Oxoquinolineribonucleosides 1a-j were prepared. These substances were screened for antiviral activity on HSV-1 virus infection, assessed by virus yield assay. The chlorosubstituted ribonucleosides 1b and 1g were the best inhibitors of HSV-1 yield with EC50 of 1.5 +/- 0.06 mu M and 1.7 +/- 0.08 M, respectively. Compound 1b presented the best selectivity index (SI) with an SI value of 1000.

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Nucleosides,oxoquinolineribonucleosides,anti-HSV-1

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