Design, Synthesis, Antibacterial and Antifungal Evaluation of 1,2,4-Triazole-thiazolidin-4-one Hybrids

A series of previously unknown [5-(substituted phenyl)-4 H -1,2,4-triazol-4-yl]thiazolidin-4-ones have been successfully synthesized, and their structure has been confirmed by IR and 1 H and 13 C NMR spectroscopy and mass spectrometry. The synthesized compounds have been tested for in vitro activity against bacterial and fungal strains. Compounds containing 4-OCH 3 , 4-NO 2 and 2,3-(OCH 3 ) 2 groups in the phenyl ring of the arylidene substituent demonstrated moderate to excellent antibacterial activity, while compounds containing 2-Br, 4-Cl, 4-F, 4-OCH 3 , 4-CH 3 , 2,4-(CH 3 ) 2 , and 4-NO 2 groups exhibited excellent to good antifungal activity. The MIC values for the 2,3-(OCH 3 ) 2 derivatives against various bacterial strains varied from 12.5 to 50 µg/mL. In terms of the antifungal activity, the 2-Br derivative showed the significant activity against C. albicans (MIC 200 µg/mL).