Chronological Changes In Brain Blood Flow And Central Benzodiazepine Receptor Binding Potential In A Patient With Symptomatic Epilepsy After Surgery For Aneurysmal Subarachnoid Hemorrhage: I-123-Iomazenil Single-Photon Emission Computed Tomography Studies

Early I-123-iomazenil single-photon emission computed tomography (SPECT) images are correlated with blood flow in the brain, and late images are correlated with cortical benzodiazepine receptor binding potential. Reduced metabolism in the contralateral cerebral hemisphere is indicated by crossed cerebellar hypoperfusion (CCH). We present the case of a 63-year-old man who developed symptomatic epilepsy 13 days after surgery for an aneurysmal subarachnoid hemorrhage. Early images on I-123-iomazenil SPECT 2 days after seizure onset revealed CCH and hyperperfusion in the affected cerebral hemisphere where benzodiazepine receptor binding potential was reduced in late images on I-123-iomazenil SPECT. These abnormal findings resolved on repeated I-123-iomazenil SPECT 1 month after seizure onset. The case we present here is consistent with the idea that the central benzodiazepine receptor system in the human brain undergoes changes that are related to seizures due to epilepsy. (C) 2017 The Author(s) Published by S. Karger AG, Basel