Formulation and Invitro Evaluation of Invitro Vildagliptin Microparticles

Vildagliptin is a new oral anti-hyperglycemic agent of the new dipeptidyl peptidase-4 inhibitor class of drugs. This hypoglycemic agent belongs to BCS class 3 and therefore has high solubility and rapidly gets excreted from the body and hence it can be converted into sustained release dosage form in order to increase its duration of action.  The objective of this study is to formulate and evaluate sustained release microparticles of vildagliptin using different proportions of natural polymers like moringa gum and natural polymer blend to increase its duration of action.  In this study the effect of different proportion of cross linking agents  were studied. Microparticles of vildagliptin were prerpared by ion cross-linking technique using cacl2 as cross-linking agent, using moringa gum alone and in combination with sodium alginate as copolymer (as release retardant agent)  with a view to deliver drug at sustained manner in GIT and consequently into systemic circulation.  Drug – excipient compatibility studies were carried out by using FT-IR.  The prepared microparticles were evaluated for particle size, angle of repose, % yield, % drug entrapment efficiency, degree of swelling and invitro drug release studies.FTIR studies showed no evidence on interactions between drug and polymer.  The percentage drug release of F1-F6 formulation at the end of 12th hour was found to be 97%,96%,82.8%,100%,91.8%,93.6% was observed.  The optimal sustained release effect was exhibited by F4 formulation.