Outcomes Following Resection Of Periampullary Adenocarcinoma As A Function Of Body Composition Assessed On Preoperative Ct.

e15289 Background: Cachexia is a common manifestation of pancreatic cancer and other periampullary adenocarcinomas. Sarcopenia (low muscle mass) is one manifestation of cachexia. Reduced skeletal muscle attenuation on CT scan also often accompanies cachexia, and this is thought to be related to fat infiltration of skeletal muscle (myosteatosis). We postulated that changes in body composition that signify cachexia adversely affect perioperative outcomes and survival. Methods: 123 patients who underwent a Whipple pancreaticoduodenectomy for pancreatic adenocarcinoma or a non-pancreatic periampullary adenocarcinoma had a preoperative CT scan available for analysis. Muscle cross sectional areas and attenuation values were measured at the level of the third lumbar vertebra. Muscle area was normalized for stature. Sarcopenia was defined as muscle index (cm2/m2) below the 25th percentile for each gender. Reduced muscle attenuation was defined as muscle attenuation below the 25thpercentile. Results: Myosteatosis ...