Organocatalytic Enantioselective Vinylogous Henry Reaction of 3,5-Dimethyl-4-nitroisoxazole with Trifluoromethyl Ketones

Ehsan Jafari,Dipti Sankar Kundu,Pankaj Chauhan,V. P. Reddy Gajulapalli,Carolina von Essen,Kari Rissanen,Dieter Enders

SYNTHESIS-STUTTGART（2018）

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摘要

The enantioselective vinylogous Henry reaction of 3,5-dimethyl-4-nitroisoxazole with trifluoromethyl ketones employing a bifunctional squaramide organocatalyst has been developed. A series of isoxazole bearing trifluoromethyl-substituted tertiary alcohols, 2-substituted (R)-1,1,1-trifluoro-3-(3-methyl-4-nitroisoxazol-5-yl)propan-2-ols, were obtained under these mild reaction conditions in good yields and moderate to good enantioselectivities

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关键词

asymmetric synthesis,isoxazole,trifluoromethyl ketone,squaramide organocatalyst,vinylogous Henry reaction

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