Synthesis of bicyclic tripeptides inspired by the ABC-ring system of vancomycin through ruthenium-based cyclization chemistries

Xin Yang, Lucas P. Beroske,Johan Kemmink,Dirk T.S. Rijkers,Rob M.J. Liskamp

Tetrahedron Letters（2017）

引用 9|浏览20

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摘要

•An efficient synthesis of highly constrained bicyclic tripeptides.•Constraining peptides by two consecutive Ru-catalyzed macrocyclizations.•Synthesis of a tripeptide motif to mimic the ABC-ring system of vancomycin.

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关键词

Macrocycles,Peptides,Peptidomimetics,Ring-closing metathesis,Ru-based azide-alkyne cycloaddition

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