Abstract 20063: Association of Physical Activity With Cardiovascular Mortality With and Without Smoking: The Strong Heart Study

Introduction: Previous studies have established the association between smoking and physical activity (PA) on cardiovascular (CV) mortality risk. However, little is known of this association and the role of inflammation in the American Indian population. Hypothesis: We hypothesized that increased PA results in reduced inflammation and CV mortality regardless of smoking status. Methods: We assessed the association between PA and smoking status on CV mortality in 4,038 adults (mean age 56±8) without evidence of CV disease in the baseline exam of the SHS (1989-1991), a longitudinal study of American Indians. PA was measured as METS-hours per week; fibrinogen was assessed as a marker of inflammation. Cox proportional hazards regression models and Kaplan Meier analysis were used to assess associations between PA, elevated fibrinogen u003e300 mg/dL, and CV mortality over 16 years in current smokers, ex-smokers and never-smokers with control for hypertension, diabetes, BMI, LDL, eGFR and age. Results: High PA was associated with a lower prevalence of elevated fibrinogen in never-smokers (39.7% vs 62.6%), ex-smokers (35.3% vs 50.6%) and current smokers (36.1% vs 50.3%, all p Conclusions: PA was associated with reduced CV mortality in ex-smokers and never-smokers, but not current smokers, among American Indians in the SHS population.