A review on 90Y-labeled compounds and biomolecules

The field of therapeutic nuclear medicine is emerging rapidly as choice of treatment in oncology and other cellular malignancies. The growth of this branch of nuclear medicine is greatly facilitated by the introduction of a number of new radiopharmaceuticals and radionuclides. Y-90-radiopharmaceuticals have confirmed their worth in medical and clinical areas in a very short span of time. The Y-90 is a radioisotope widely used for therapeutic purposes and considerable perfection has been made to understand the chemistry of Y-90-labeled radiopharmaceuticals. The development of these radiopharmaceuticals can be made favorable by using appropriate buffer, incubation period, optimal pH, specific activity and reaction temperature. In this review, we have discussed the preparation of range of Y-90 transporting biological molecules such as antibodies radiolabeled peptides, antigens and microsphere with their clinical applications.