Selective oncolytic effect in Epstein-Barr virus (EBV)-associated gastric carcinoma through efficient lytic induction by Euphorbia extracts

Dong-eun Kim,Sunhee Jung,Hyung Won Ryu,Miri Choi,Mingu Kang,Hyunju Kang,Heung Joo Yuk,Hyejeong Jeong,Jiyeon Baek,Jae-Hyoung Song,Janghwan Kim,Hyojeung Kang,Sang-Bae Han,Sei-Ryang Oh,Sungchan Cho

Journal of Functional Foods（2018）

引用 3|浏览11

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摘要

•Identification of three Euphorbia extracts with EBV lytic-inducing activity.•Euphorbia extracts efficiently induce lytic replication in most of cell population.•Euphorbia extracts induce EBV reactivation through modulating PKC/MEK pathway.•PMA analogs in Euphorbia extracts contribute to lytic induction of EBV.•E. pekinensis extract has an oncolytic effect selectively on EBV-positive gastric carcinoma cells.

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关键词

Epstein-Barr virus,EBV-associated gastric carcinoma,Lytic induction,Medicinal plant extracts,Euphorbia

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