The epigenetic writer LSD1 controls hepatic cell cycle progression by alteration of global expression profiles and protein signatures

Chronic liver disease is one of the major health problems worldwide. The common development process of chronic liver disease is characterized by fibrosis with a high risk to end up in hepatocellular carcinoma (HCC). The lysine-specific histone demethylase, modifying the histone 3 methylation state, is a major epigenetic writer that is known to affect tumour growth. However, its function in chronic liver disease and liver cancer has not yet been addressed. In the present study we therefore investigated its hepatic function by global transcriptomic and proteomic analysis in liver cancer cells and hepatic stellate cells (HSC).